ea0086p51 | Metabolism, Obesity and Diabetes | SFEBES2022
Miedzybrodzka Emily
, Alcaino Constanza
, Guccio Nunzio
, Smith Christopher
, Lu Van
, Bany Bakar Rula
, Gribble Fiona
, Reimann Frank
The majority of the bodys 5-HT (serotonin) is produced from enterochromaffin cells (ECs) of the intestinal epithelium. 5-HT has important roles within the gastrointestinal tract in the modulation of motility, secretion and inflammation, while also signalling satiety and discomfort to the central nervous system. The factors regulating release of 5-HT from human small intestinal ECs have not been clearly elucidated: although circulating 5-HT levels typically increase after...